反应详情

N-tert-Butyl-3-[2-(2-hydroxymethyl-3H-benzoimidazol-5-ylamino)-pyrrolo[2,1-f][1,2,4]triazin-7-yl]-benzenesulfonamide was prepared from N-tert-butyl-3-(2-hydroxy-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-benzenesulfonamide and (6-amino-1H-benzoimidazol-2-yl)-methanol; dihydrochloride in an analogous manner to Example 1052a. Product isolated as a yellow foam (37 mg, 26%). LCMS (m/e) 492 (M+H); 1H-NMR (CDCl3, 400 MHz) δ 10.71 (bs, 1H), 9.00 (s, 1H), 8.68 (s, 1H), 8.17 (s, 1H), 7.90 (d, 1H, J=7.8 Hz), 7.83 (d, 1H, J=7.5 Hz), 7.65-7.54 (m, 1H), 7.44 (d, 1H, J=8.4 Hz), 7.08 (s, 1H), 6.96 (d, 1H, J=4.6 Hz), 6.82 (d, 1H, J=4.7 Hz), 6.73 (bs, 1H), 5.92 (bs, 1H), 4.89 (s, 2H), 2.62 (s, 1H), 1.24 (s, 9H).