Tetrafluoro-m-phenylenediamine dihydrochloride → {6-[7-(2-Methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-1H-benzoimidazol-2-yl}-methanol

関与物質

役割	名称	HCID	仕込み量
反応物	Tetrafluoro-m-phenylenediamine dihydrochloride	HCID 149026	—
反応物	(5-Amino-1H-benzo[d]imidazol-2-yl)methanol	HCID 838521	—
反応物	7-(2-Methoxyphenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ol	HCID 178489276	—
生成物	{6-[7-(2-Methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-1H-benzoimidazol-2-yl}-methanol	HCID 66712292	—

反応手順

{6-[7-(2-Methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-1H-benzoimidazol-2-yl}-methanol was prepared from 7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ol and (6-amino-1H-benzoimidazol-2-yl)-methanol; dihydrochloride in an analogous manner to Example 1052a. Product isolated as a yellow solid (55 mg, 46%). m.p.=239-243° C.; LCMS (m/e) 387 (M+H); 1H-NMR (d6-DMSO, 400 MHz) δ 12.05 (bs, 1H), 9.23 (s, 1H), 8.93 (s, 1H), 8.15-7.42 (m, 2H), 7.87 (d, 1H, J=7.2 Hz), 7.50-7.40 (m, 1H), 7.40-7.22 (m, 1H), 7.22 (d, 1H, J=8.3 Hz), 7.19-7.07 (m, 1H), 6.99-6.85 (m, 2H), 5.60 (bs, 1H), 4.64 (s, 2H), 3.83 (s, 3H).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08471005B2
出典データセット	uspto-grants-2013_06
ORD ID	ord-4869209ecd2b4049aa20d30884ffbc36
出典メモ	uspto-grants-2013_06