3-(3-Aminophenyl)-1,4-dimethylpiperazin-2-one → HCID 66712051, compound

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Reaction Steps

N-(2-{2-[3-(1,4-Dimethyl-3-oxo-piperazin-2-yl)-phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-7-yl}-phenyl)-N-methyl-methanesulfonamide was prepared from N-[2-(2-hydroxy-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide and 3-(3-amino-phenyl)-1,4-dimethyl-piperazin-2-one in an analogous manner to Example 1052a. Product isolated as a brown foam (72 mg, 46%). LCMS (m/e) 520 (M+H); 1H-NMR (CDCl3, 400 MHz) δ 8.72 (s, 1H), 7.89-7.82 (m, 1H), 7.54-7.45 (m, 4H), 7.38 (s, 1H), 7.20-7.12 (m, 1H), 7.02-6.92 (m, 2H), 6.89-6.81 (m, 2H), 3.70-3.60 (m, 1H), 3.52 (s, 1H), 3.24-3.15 (m, 1H), 3.11 (s, 3H), 3.01-2.92 (m, 1H), 2.97 (s, 3H), 2.68-2.55 (m, 1H), 2.62 (s, 3H), 2.08 (s, 3H).

Provenance & Evidence