4-(Pyridin-3-yl)aniline → N-tert-Butyl-3-[2-(4-pyridin-3-yl-phenylamino)-pyrrolo[2,1-f][1,2,4]triazin-7-yl]-benzenesulfonamide

Participants

Reaction Steps

N-tert-Butyl-3-[2-(4-pyridin-3-yl-phenylamino)-pyrrolo[2,1-f][1,2,4]triazin-7-yl]-benzenesulfonamide was prepared from N-tert-butyl-3-(2-hydroxy-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-benzenesulfonamide and 4-pyridin-3-yl-phenylamine in an analogous manner to Example 1052a. Product isolated as a pale yellow solid (14 mg, 9%). m.p.=250-253° C.; LCMS (m/e) 499 (M+H); 1H-NMR (CDCl3, 400 MHz) δ 8.90 (s, 1H), 8.80 (s, 1H), 8.78 (s, 1H), 8.57 (s, 1H), 8.26 (d, 1H, J=7.8 Hz), 7.95 (d, 1H, J=7.9 Hz), 7.89 (d, 1H, J=7.9 Hz), 7.75 (d, 1H, J=8.5 Hz), 7.69 (d, 1H, J=8.5 Hz), 7.65-7.57 (m, 1H), 7.44-7.32 (m, 1H), 7.10 (d, 1H, J=4.7 Hz), 6.97 (s, 1H), 6.89 (d, 1H, J=4.7 Hz), 1.18 (s, 9H).

Provenance & Evidence