4-(Pyridin-3-yl)aniline → (4-Pyridin-3-yl-phenyl)-{7-[3-(pyrrolidine-1-sulfonyl)-phenyl]-pyrrolo[2,1-f][1,2,4]triazin-2-yl}-amine

Participants

Reaction Steps

(4-Pyridin-3-yl-phenyl)-{7-[3-(pyrrolidine-1-sulfonyl)-phenyl]-pyrrolo[2,1-f][1,2,4]triazin-2-yl}-amine was prepared from 7-[3-(pyrrolidine-1-sulfonyl)-phenyl]-pyrrolo[2,1-f][1,2,4]triazin-2-ol and 4-pyridin-3-yl-phenylamine in an analogous manner to Example 1052a. Product isolated as a yellow solid (88 mg, 58%). m.p.=194-200° C.; LCMS (m/e) 497 (M+H); 1H-NMR (CDCl3, 400 MHz) δ 8.87 (s, 1H), 8.78 (s, 1H), 8.56 (d, 1H, J=4.3 Hz), 8.53 (s, 1H), 8.43 (d, 1H, J=8.0 Hz), 7.91 (d, 1H, J=8.0 Hz), 7.84 (d, 1H, J=7.8 Hz), 7.74 (d, 1H, J=8.6 Hz), 7.71-7.61 (m, 3H), 7.35 (dd, 1H, J=4.9 and 7.7 Hz), 7.09 (d, 1H, J=4.8 Hz), 6.98 (s, 1H), 6.89 (d, 1H, J=4.8 Hz), 3.36-3.22 (m, 4H), 1.83-1.72 (m, 4H).

Provenance & Evidence