4-(Pyridin-3-yl)aniline → N-Methyl-N-{2-[2-(4-pyridin-3-yl-phenylamino)-pyrrolo[2,1-f][1,2,4]triazin-7-yl]-phenyl}-methanesulfonamide

Participants

Reaction Steps

N-Methyl-N-{2-[2-(4-pyridin-3-yl-phenylamino)-pyrrolo[2,1-f][1,2,4]triazin-7-yl]-phenyl}-methanesulfonamide was prepared from N-[2-(2-hydroxy-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-N-methyl-methanesulfonamide and 4-pyridin-3-yl-phenylamine in an analogous manner to Example 1052a. Product isolated as a yellow foam (71 mg, 50%). LCMS (m/e) 471 (M+H); 1H-NMR (CDCl3, 400 MHz) δ 8.82 (s, 1H), 8.75 (s, 1H), 8.55 (d, 1H, J=4.6 Hz), 8.00-7.91 (m, 1H), 7.83 (d, 1H, J=8.1 Hz), 7.60 (d, 2H, J=7.9 Hz), 7.59-7.49 (m, 3H), 7.45 (d, 2H, J=7.7 Hz), 7.39-7.30 (m, 1H), 7.07 (d, 1H, J=4.0 Hz), 6.95-6.85 (m, 2H), 3.15 (s, 3H), 2.72 (s, 3H).

Provenance & Evidence