(7-Bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine → HCID 46851382, compound

HRID 1262284Notes

Reaction equation

HRID 1262284 reaction equation
Br[C:2]1[N:10]2[C:5]([CH:6]=[N:7][C:8](NC3C=CC(N4CCN(C)CC4)=CC=3)=N2)=[CH:4][CH:3]=1.Br[C:26]1[N:34]2[C:29]([CH:30]=[N:31][C:32]([NH:35][C:36]3[CH:41]=[CH:40][CH:39]=[C:38]([N:42]4[CH2:47][CH2:46][N:45]([CH3:48])[CH2:44][CH2:43]4)[CH:37]=3)=[N:33]2)=[CH:28][CH:27]=1>>[CH3:48][N:45]1[CH2:46][CH2:47][N:42]([C:38]2[CH:37]=[C:36]([NH:35][C:32]3[N:31]=[CH:30][C:29]4=[CH:28][CH:27]=[C:26]([NH:10][CH2:2][C:3]5[CH:8]=[N:7][CH:6]=[CH:5][CH:4]=5)[N:34]4[N:33]=3)[CH:41]=[CH:40][CH:39]=2)[CH2:43][CH2:44]1

Participants

3

Reactant 2

HCID 66711200(7-Bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amineHCID 66711673HCID 66711673, compound

Product 1

HCID 46851382HCID 46851382, compound

Procedure

The titled compound was prepared in an analogous fashion to Example 1164 replacing (7-Bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine with (7-Bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[3-(4-methyl-piperazin-1-yl)-phenyl]-amine to give a yellow solid (65 mg, 60%). LCMS (E/I+) 415.19 (M+H). NMR 1H (DMSO-d6)-9.90 (bs, 1H), 1.41 (s, 1H), 8.73 (s, 1H), 8.62 (d, 1H, J=4.97 Hz), 8.4 (s, 1H), 8.06 (d, 1H, J=7.45 Hz), 7.61 (t, 1H, J=5.79 Hz), 7.48 (bs, 1H), 7.37 (d, 1H, J=7.45 Hz), 7.24 (d, 1H, J=7.45 Hz), 7.19 (s, 1H), 7.16 (d, 1H, J=4.97 Hz), 6.70 (d, 1H, J=8.28 Hz), 6.66 (d, 1H, J=4.57 Hz), 4.71 (s, 2H), 3.86 (bs, 2H), 3.47 (bs, 2H), 3.14 (bs, 2H), 2.98 (bs, 4H), 2.86 (s, 3H).

Sources & evidence

ORD record
ord-bb3346e972954bb18f4fa8866673dc6e
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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