反应详情

To a solution of 4-{2-[4-(3-Methoxy-4-nitro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-acetyl}-piperazine-1-carboxylic acid tert-butyl ester (250 mg, 0.54 mmol) in methanol (20 mL) was added 10% Palladium on Carbon (50% Wet, 58 mg, 0.027 mmol). The mixture was shaken in a Parr apparatus under an atmosphere of Hydrogen (50 PSI) overnight. Filtration through Celite and evaporation of the solvent provided crude 4-{2-[4-(4-Amino-3-methoxy-phenyl)-piperidin-1-yl]-acetyl}-piperazine-1-carboxylic acid tert-butyl ester, which was used without further purification.

1. filtrationFiltration
2. customthrough Celite and evaporation of the solvent