反应详情

To a solution of [4-(3-Methoxy-4-nitro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-acetic acid tert-butyl ester (145 mg, 0.416 mmol) in methanol (15 mL, 370 mmol) was added 10% Palladium on Carbon (50% Wet, 44.3 mg, 0.0208 mmol). The mixture was shaken in a Parr apparatus under an atmosphere of Hydrogen (50 PSI) for 3 h. Filtration through Celite and evaporation of the solvent provided crude [4-(4-Amino-3-methoxy-phenyl)-piperidin-1-yl]-acetic acid tert-butyl ester, which was used without further purification.

1. filtrationFiltration
2. customthrough Celite and evaporation of the solvent