5-Amino-2-hydroxybenzimidazole → HCID 46851203, compound

Participants

Reaction Steps

Following the synthetic and purification procedures described in Example 1293d, 2-methanesulfinyl-7-(4-methanesulfonyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazine (75 mg, 0.22 mmol) was coupled with 5-amino-1,3-dihydro-benzimidazol-2-one (57 mg, 0.38 mmol) at 105° C. for 86 h to afford the title compound. Yield of TFA salt: 79 mg (67%) of brown powder. LC/MS: 421 (M+H); HPLC: 97% pure, RT=2.32 min; 1H NMR: (DMSO, δ) 10.65 (s, 1H), 10.48 (s, 1H), 9.38 (s, 1H), 9.02 (s, 1H), 8.49 (d, J=8.6, 2H), 8.04 (d, J=8.6, 2H), 7.35 (m, 2H), 7.29 (s, 1H), 6.98 (d, J=4.8, 1H), 6.91 (d, J=8.6, 1H), 3.27 (s, 3H).

Provenance & Evidence