5-Aminobenzimidazole → HCID 66712833, compound

Participants

Reaction Steps

Following the synthetic and purification procedures described in Example 1293d, 2-methanesulfinyl-7-(4-methanesulfonyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazine (75 mg, 0.22 mmol) was coupled with 3H-benzimidazol-5-ylamine (51 mg, 0.38 mmol) at 105° C. in a for 86 h to afford the title compound. Yield of TFA salt: 46 mg (40%) of brown powder; LC/MS: 405 (M+H); HPLC: 90% pure, RT=2.14 min; 1H NMR: (DMSO, δ) 9.96 (s, 1H), 9.48 (s, 1H), 9.13 (s, 1H), 8.51 (d, J=8.6, 2H), 8.18 (s, 1H), 8.07 (d, J=8.6, 2H), 7.86 (m, 2H), 7.42 (d, J=4.8, 1H), 7.07 (d, J=4.8, 1H), 3.28 (s, 3H)-benzimidazole NH presumably underwent rapid exchange with residual water.

Provenance & Evidence