5-Aminobenzimidazole → (3H-Benzimidazol-5-yl)-[7-(3-cyclopropylmethanesulfonyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-amine

Participants

Reaction Steps

Following the synthetic and purification procedures described in Example 1293d, 7-(3-cyclopropylmethanesulfonyl-phenyl)-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine (75 mg, 0.20 mmol) was coupled with 3H-benzimidazol-5-ylamine (45.2 mg, 0.340 mmol) at 105° C. for 86 h to afford the title compound. Yield of TFA salt: 39 mg (43%) of brown powder; LC/MS: 445 (M+H); HPLC: 97% pure, RT=2.46 min; 1H NMR: (DMSO, δ) 9.85 (s, 1H), 9.33 (s, 1H), 9.02 (s, 1H), 8.51 (s, 1H), 8.45 (d, J=7.7, 1H), 8.00 (s, 1H), 7.90 (dd, J=9.2, 1.5, 1H), 7.83 (d, J=7.7, 1H), 7.75 (m, 2H), 7.27 (d, J=4.8, 1H), 6.97 (d, J=4.8, 1H), 3.21 (d, J=7.1, 2H), 0.77 (m, 1H), 0.34 (m, 2H), 0.01 (m, 2H).

Provenance & Evidence