2-[4-(4-Aminophenyl)piperidin-1-yl]acetamide → HCID 66711720, compound

HRID 1262382Notes

Reaction equation

HRID 1262382 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[C:10]1[N:18]2[C:13]([CH:14]=[N:15][C:16](S(C)=O)=[N:17]2)=[CH:12][CH:11]=1.[NH2:22][C:23]1[CH:28]=[CH:27][C:26]([CH:29]2[CH2:34][CH2:33][N:32]([CH2:35][C:36]([NH2:38])=[O:37])[CH2:31][CH2:30]2)=[CH:25][CH:24]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[C:10]1[N:18]2[C:13]([CH:14]=[N:15][C:16]([NH:22][C:23]3[CH:28]=[CH:27][C:26]([CH:29]4[CH2:30][CH2:31][N:32]([CH2:35][C:36]([NH2:38])=[O:37])[CH2:33][CH2:34]4)=[CH:25][CH:24]=3)=[N:17]2)=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 574161072-[4-(4-Aminophenyl)piperidin-1-yl]acetamideHCID 66711254HCID 66711254, compound

Product 1

HCID 66711720HCID 66711720, compound

Procedure

Following the synthetic and purification procedures of Example 1291c, 7-(2-Fluoro-6-methoxy-phenyl)-2-methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazine (79 mg, 0.26 mmol) was coupled to 2-[4-(4-amino-phenyl)-piperidin-1-yl]-acetamide (91 mg, 0.39 mmol) in a sealed vial at 125° C. for 96 h followed by 6 h in a microwave reactor at 170° C. Yield of

Workup

  1. customsealed vial at 125° C.
  2. customfor 96 h

Sources & evidence

ORD record
ord-ffe4812210064c94a74dcc5a29545bff
Source dataset
uspto-grants-2013_06
Patent number
US08471005B2

Reaction notes

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