Dichloromethane → HCID 66712594, compound

Participants

Reaction Steps

[2-(2-Methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenoxy]-acetic acid tert-butyl ester (0.298 g, 0.769 mmol), Methylene chloride (11 mL, 170 mmol), and Trifluoroacetic Acid (2.20 mL, 28.5 mmol) were combined and stirred for 18 hours. The product was extracted into dichloromethane and purified by normal phase silica gel chromatography eluting with methanol/dichloromethane to yield a brown solid, [2-(2-Methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenoxy]-acetic acid (197 mg, 77%). LCMS: m/z=332.06 (M+H+); 1H NMR (400 MHz, DMSO-d6) δ 9.30 (s, 1H), 7.86 (d, 1H, J=7.6 Hz), 7.54 (d, 1H, J=4.7 Hz), 7.46 (m, 1H), 7.31 (d, 1H, J=4.7 Hz), 7.14 (m, 2H), 4.77 (s, 2H), 2.92 (s, 3H).

Provenance & Evidence