Dimethylformamide → HCID 66711099, compound

Participants

Reaction Conditions

Reaction Steps

4-[1-(3-Methoxy-4-nitro-phenyl)-piperidin-3-yl]-piperazine-1-carboxylic acid benzyl ester: To a mixture of 4-piperidin-3-yl-piperazine-1-carboxylic acid benzyl ester, compound with trifluoro-acetic acid (10.0 g, 24.0 mmol) and potassium carbonate (8.3 g, 6.0 mmol) in DMF (100 mL) was added 4-fluoro-2-methoxy-1-nitro-benzene (4.1 g, 24 mmol) with stirring. The mixture was heated at 60° C. for 18 hours. The solvent was removed on the rotovap and the residue was partitioned between dichloromethane and water, the organic phase was washed with sat'd aq. sodium bicarbonate and brine, dried over anhydrous magnesium sulfate, filtered and concentrated. Flash chromatography over silica gel provided 9.2 g of the title compound. MS=455 (M+1).

Provenance & Evidence