HCID 66711722, compound → HCID 66712498, compound

Participants

Reaction Steps

2-(4-Nitro-phenyl)-piperazine-1,4-dicarboxylic acid di-tert-butyl ester (0.440 g, 1.08 mmol) was dissolved in Methanol (40 mL) and transferred to a Parr bottle containing 5% Platinum on Carbon, Sulfided (0.5%) (65 mg, 0.017 mmol). The mixture was shaken under an atmosphere of Hydrogen (10 psi) for 2 h, then filtered and conc. in vacuo to afford 2-(4-Amino-phenyl)-piperazine-1,4-dicarboxylic acid di-tert-butyl ester (0.37 g, 91%). 1H-NMR (DMSO-d6): 6.88 (d, 2H, J=8.0 Hz), 6.51 (d, 2H, J=8.0 Hz), 5.00 (m, 3H), 4.26 (m, 1H), 3.77 (m, 2H), 3.16 (m, 1H), 2.84 (m, 2H), 1.39 (s, 9H), 1.35 (s, 9H).

Provenance & Evidence