3-Chloropropanesulphonyl chloride → HCID 66712784, compound

Participants

Reaction Steps

Analogous to Example 1506b, 2-(2-Methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenylamine (0.777 g, 3.03 mmol) was reacted with 3-Chloropropane-1-sulfonyl chloride to afford 7-[2-(1,1-Dioxido-1,2-thiazolidin-2-yl)phenyl]-2-(methylsulfanyl)pyrrolo[2,1-f][1,2,4]triazine as a yellow solid (83 mg, 8%). 1H-NMR (DMSO-d6): 8.79 (s, 1H), 7.84 (dd, 1H, J=5.04 Hz), 7.72 (dd, 1H, J=5.04 Hz), 7.46 (m, 2H), 7.29 (d, 1H, J=4.72 Hz), 6.91 (d, 1H, J=4.72 Hz), 3.38 (t, 2H, J=6.81), 3.19 (t, 2H, J=7.49), 2.48 (s, 3H), 2.27 (quin, 2H, J=7.49).

Provenance & Evidence