m-Aminoacetanilide → HCID 66712906, compound

Participants

Reaction Steps

Analogous to Example 1510b, 7-(3-tert-Butoxymethyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ol (109 mg, 0.37 mmol) and 3′-aminoacetanilide (0.0689 g, 0.459 mmol) were reacted to afford N-{3-[7-(3-tert-Butoxymethyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-acetamide as an orange foam (62 mg, 39%). LCMS: 430 (M+H); 1H-NMR (DMSO-d6): 9.84 (s, 1H), 9.46 (s, 1H), 8.98 (s, 1H), 8.12 (s, 1H), 8.06 (d, 1H, J=7.71 Hz), 7.72 (s, 1H), 7.63 (d, 1H, J=7.71 Hz), 7.44 (t, 1H, J=7.71 Hz), 7.35 (d, 1H, J=7.71 Hz), 7.22 (m, 2H), 7.19 (d, 1H, 4.65 Hz), 6.96 (d, 1H, J=4.65 Hz), 4.46 (s, 2H), 2.03 (s, 3H), 1.22 (s, 9H).

Provenance & Evidence