2-(Tributylstannyl)pyrimidine → 2-(Methylsulfanyl)-7-(pyrimidin-2-yl)pyrrolo[2,1-f][1,2,4]triazine

Participants

Reaction Steps

Analogous to Example 1562a, 2-Tributylstannanyl-pyrimidine (0.761 g, 2.06 mmol) and 7-Bromo-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine (0.224 g, 0.916 mmol) were reacted to afford 2-Methylsulfanyl-7-pyrimidin-2-yl-pyrrolo[2,1-f][1,2,4]triazine (46 mg, 20%). 1H-NMR (DMSO-d6): 9.14 (s, 1H), 8.95 (d, 2H, J=4.94 Hz), 7.58 (m, 1H), 7.44 (t, 1H, J=4.83 Hz), 7.10 (d, 1H, J=4.83 Hz), 2.59 (s, 3H).

Provenance & Evidence