Ethylene Glycol → HCID 178495622, compound

Participants

Reaction Steps

Into a 2 l three-neck flask were added compound (F) (25 g, 0.109 mol) obtained in the fifth step and ethylene glycol (722 ml) and further an aqueous solution obtained by dissolving KOH (18.8 g, 0.335 mol) in water (26 ml), followed by refluxing the mixture for 12 hours while heating on a mantle heater. After cooling, the reaction mixture was acidified by adding 6N-HCl (200 ml) to form crystals, which were filtered off and dried, followed by dissolving the crystals in ethanol (200 ml) and recrystallizing to obtain 4-(trans-4'-methyloxymethylcyclohexyl)benzoic acid (G) (18.8 g). This had a melting point (C-N point) of 132.7° C. and a clearing point (N-I point) of 234.6° C.

Provenance & Evidence