Hydrochloric Acid → HCID 20456877, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 31.9 gm of 3-[(3,4-dimethoxy-phenyl)-2-ethylaminocarbonyl]-furan-4-carboxylic acid ethyl ester in 150 ml of methanol was admixed with 150 ml of 1 N sodium hydroxide, and the mixture was stirred for 45 minutes at 50° C. The reaction mixture was then neutralized with hydrochloric acid, the solvent was distilled off, and the desired reaction product was extracted from the residue with methylene chloride and crystallized from ethyl acetate/petroleum ether.

Provenance & Evidence