HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-(4-Bromobutyl)-8-azaspiro(4.5)decane-7,9-dione → 8-[4-[4-(1,2-Benzisoxazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hemihydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-(4-Bromobutyl)-8-azaspiro(4.5)decane-7,9-dione | HCID 11208851 | — |
| Reactant | 3-(Piperazin-1-yl)-1,2-benzoxazole | HCID 13232475 | — |
| Product | 8-[4-[4-(1,2-Benzisoxazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hemihydrate | HCID 70508187 | 40% |
Reaction Steps
Reaction of 8-(4-bromobutyl)-8-azaspiro[4.5]decane-7,9-dione and 3-(1-piperazinyl)-1,2-benzisoxazole according to the procedure of Example 3 and crystallization of the free base from isopropanol affords a 40% yield of 8-[4-[4-(1,2-benzisoxazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hemihydrate, m.p. 96°-98° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04452799 |
| Source dataset | uspto-grants-1984_06 |
| ORD ID | ord-e26478b8b9c84aef870bc1b12929a5de |
| Source note | uspto-grants-1984_06 |