HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Bromobutyl)-1,3-thiazolidine-2,4-dione → 3-[4-[4-(1,2-Benzisoxazol-3-yl)-1-piperazinyl]butyl]-2,4-thiazolidinedione hydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Bromobutyl)-1,3-thiazolidine-2,4-dione | HCID 13059825 | — |
| Reactant | 3-(Piperazin-1-yl)-1,2-benzoxazole | HCID 13232475 | — |
| Product | 3-[4-[4-(1,2-Benzisoxazol-3-yl)-1-piperazinyl]butyl]-2,4-thiazolidinedione hydrate | HCID 20456952 | 44% |
Reaction Steps
Reaction of 3-(4-bromobutyl)-2,4-thiazolidinedione with 3-(1-piperazinyl)-1,2-benzisoxazole according to the procedure of Example 3 affords a 44% yield of 3-[4-[4-(1,2-benzisoxazol-3-yl)-1-piperazinyl]butyl]-2,4-thiazolidinedione hydrate, m.p. 104.5°-106.6° C., from methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04452799 |
| Source dataset | uspto-grants-1984_06 |
| ORD ID | ord-87ea85affb1a402392ed4cddde98e883 |
| Source note | uspto-grants-1984_06 |