2-(2-(2-(Dipropylamino)ethyl)-6-nitrophenyl)acetic acid hydrochloride → Ropinirole Hydrochloride

HRID 1262585노트

반응식

HRID 1262585 반응식
[ClH:1].[N+:2]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH2:12][N:13]([CH2:17][CH2:18][CH3:19])[CH2:14][CH2:15][CH3:16])[C:6]=1[CH2:20][C:21]([OH:23])=O)([O-])=O>C(O)C.[Pd]>[ClH:1].[CH2:14]([N:13]([CH2:17][CH2:18][CH3:19])[CH2:12][CH2:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:5]2[C:6]=1[CH2:20][C:21](=[O:23])[NH:2]2)[CH2:15][CH3:16]

참가 물질

4

반응물 1

HCID 135309012-(2-(2-(Dipropylamino)ethyl)-6-nitrophenyl)acetic acid hydrochloride

생성물 1

HCID 68727Ropinirole Hydrochloride수율 77.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 5.83 g (16.9 mmoles) of 2-nitro-6-(2-di-n-propylaminoethyl)-phenyl acetic acid hydrochloride and 0.6 g of 5% palladium-on-carbon in 250 cc of ethanol was hydrogenated at 50 p.s.i. over 5.5 hours. The catalyst was filtered, washed with ethanol, and the filtrate evaporated to dryness in vacuo. The white residue was crystallized from 550 cc of hot acetonitrile to give 3.89 g of 4-(2-di-n-propylaminoethyl)-2(3H)indolone hydrochloride, mp 240°-2°.

후처리

  1. filtrationThe catalyst was filtered
  2. washwashed with ethanol
  3. customthe filtrate evaporated to dryness in vacuo
  4. customThe white residue was crystallized from 550 cc of hot acetonitrile

출처 및 근거

ORD 기록
ord-1bbeec1a42f64d6da31867bfa9097a5c
출처 데이터셋
uspto-grants-1984_06
특허 번호
US04452808

반응 노트

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