反应详情

A solution of 4-chloro-2-fluoro-5-isopropoxy-aniline (30 g) in toluene (100 ml) was added to a 1 M phosgene/toluene solution (500 ml) at room temperature (ca. 20° C.), followed by heating under reflux. The mixture was concentrated under reduced pressure, and the residue was distilled to give 26 g of 4-chloro-2-fluoro-5-isopropoxy-phenyl isocyanate as pale yellow crystals. M.P., 36°-37° C. B.P., 90°-91° C./3 mmHg.

1. temperatureby heating
2. temperatureunder reflux
3. concentrationThe mixture was concentrated under reduced pressure
4. distillationthe residue was distilled