反应详情

17.9 g (0.089 mol) of 2 guanidino-4-thiazole carboxylic acid hydrazide was combined with 24.9 g of 2-methyl-2-thiopseudourea sulfate (0.089 mol) and heated rapidly to reflux in 125 ml dimethylsulfoxide. The reactants dissolved and within 5 minutes reflux a heavy precipitate formed. Reflux was continued for a total of 30 minutes. The reaction was cooled and the resulting heavy precipitate was isolated by filtration and washed with a small portion of dimethylsulfoxide followed by washing with isopropyl alcohol and ether. The resulting solid was dried in vacuo to give 34.6 g of 2-guanidino-4-thiazole carboxylic acid 2-amidinohydrazide containing some occluded dimethylsulfoxide.

1. temperatureheated rapidly
2. dissolutionThe reactants dissolved and within 5 minutes
3. temperaturereflux a heavy precipitate
4. customformed
5. temperatureReflux
6. customwas continued for a total of 30 minutes
7. temperatureThe reaction was cooled
8. customthe resulting heavy precipitate was isolated by filtration
9. washwashed with a small portion of dimethylsulfoxide
10. washby washing with isopropyl alcohol and ether
11. customThe resulting solid was dried in vacuo