Syringaldehyde → 3,4,5-Trimethoxybenzaldehyde

Participants

Reaction Conditions

Reaction Steps

In an apparatus as in Example 1, 10.0 g (0.054 mol) of syringaldehyde and 5.00 g (0.036 mol) of potassium carbonate were heated to 100° C. and 8 ml (0.094 mol) of dimethyl sulfite was added over a 5 minute period. The pasty mixture was heated to 100° C. for 3 hours then cooled to 25° C. and quenched with 50 ml water. The mixture was extracted with 100 ml of methylene chloride. The extracts were washed with water and concentrated in vacuo to get 4.2 g (54% based on recovered syringaldehyde) of 3,4,5-trimethoxybenzaldehyde.

Provenance & Evidence