反应详情

To 1350 grams of polyphosphoric acid at 100° to 110° C., there is added portionwise 89.3 g. (0.307 mole) of 1-(5-methyl-3-phenyl-4-isoxazolyl)-1-ethanone phenyl hydrazone, while maintaining the temperature between 105° and 115° C. After addition is complete the mixture is stirred at 100° to 110° C. for 3 hours. The mixture is then poured onto ice and water and the resulting solid is filtered and washed with water. The solid is then dissolved in ether, washed with water, dried and evaporated partially and cooled in ice. The resulting solid is filtered and washed with cold ether to give 2-(5-methyl-3-phenyl-4-isoxazolyl)-indole; m.p. 145° to 146° C.

1. additionAfter addition
2. filtrationthe resulting solid is filtered
3. washwashed with water
4. dissolutionThe solid is then dissolved in ether
5. washwashed with water
6. customdried
7. customevaporated partially
8. temperaturecooled in ice
9. filtrationThe resulting solid is filtered
10. washwashed with cold ether