Syringaldehyde → 3,4,5-Trimethoxybenzaldehyde

Participants

Reaction Conditions

Reaction Steps

In an apparatus similar to Example 1, 15.2 g (0.083 mol) of syringaldehyde and 15.0 g (0.11 mol) of potassium carbonate were heated to 105° C. under nitrogen and 15 ml (0.12 mol) of trimethyl phosphate were added over 10 minutes. The mixture was maintained at about 80° C. for 3 hours then cooled to 45° C. and quenched with 50 ml of H2O. The tan solid which precipitated was collected, washed with 3×50 ml of water and dried to give 15 g (92%) of 3, 4, 5-trimethoxybenzaldehyde.

Provenance & Evidence