Sodium Chlorite → HCID 53917414, compound

Participants

Reaction Steps

6-(4'-Biphenylyl)-6-chloro-5-formyl-hex-5-enoic acid methyl ester (1 g) was dissolved in t-BuOH (75 mL). A solution of NaClO2 (2.42 g) and NaH2PO4 (2.42 g) in 25 mL H2O was added dropwise. The solution was stirred for 16 hours. The methanol was removed in vacuo. The solution was acidified (3N HCl) and the product ester 12 extracted with EtOAc. 1 g, 95%. NMR and IR spectra of 12 were obtained.

Provenance & Evidence