Trifluoroacetic acid → HCID 178501866, compound

Participants

Reaction Steps

To a solution of benzhydryl 7-[4-chloro-2-methoxycarbonylmethoxyimino-3-oxobutyramido]-3-methylthio-3-cephem-4-carboxylate (syn isomer) (12.65 g) and anisole (8.5 g) in dichloromethane (30 ml) was added trifluoroacetic acid (36.5 g) under ice-cooling and the mixture was stirred at ambient temperature for 1.5 hours. The reaction mixture was dropwise added to a mixture of isopropyl ether and n-hexane (1:1 400 ml) under stirring. The precipitates were collected by filtration and washed with n-hexane to give 7-[4-chloro-2-methoxycarbonylmethoxyimino-3-oxobutyramido]-3-methylthio-3-cephem-4-carboxylic acid (syn isomer) (7.3 g).

Provenance & Evidence