m-Chloroperbenzoic acid → HCID 131713534, compound

Participants

Reaction Steps

To a solution of benzhydryl 7-[2-(2-formamidothiazol-4-yl)-2-tert-butoxycarbonylmethoxyiminoacetamido]-3-tosyloxy-3-cephem-4-carboxylate (syn isomer) (3.2 g) in methylene chloride (20 ml) was added m-chloroperbenzoic acid (1.62 g) at ambient temperature. The mixture was stirred for an hour. The resulting solution was concentrated under reduced pressure and the residue was subjected to column chromatography on silica gel (eluent: benzene-ethyl acetate) to give benzhydryl 7-[2-(2-formamidothiazol-4-yl)-2-tert-butoxycarbonylmethoxyiminoacetamido]-3-tosyloxy-3-cephem-4-carboxylate-1-oxide (syn isomer), 0.6 g).

Provenance & Evidence