Methyl Isocyanate → HCID 53713561, compound

Participants

Reaction Steps

A mixture of 3.0 g (0.017 m) of 1-(2-carbamoyl-1-methylethylthio)acetaldoxime, 200 ml. of dry acetone, 3.0 g. (0.053 m) of methyl isocyanate, and two drops of triethylamine was allowed to stand at room temperature, with occasional shaking, for two days. The acetone and excess methyl isocyanate was removed from the product under reduced pressure. The white solid residue was recrystallized from isopropanol and dried at room temperature to give 3.0 g (75% yield) of 1-(2-carbamoyl-1-methylethylthio)acetaldehyde O-(methylcarbamoyl)oxime; melting point=119-121. The nmr spectra confirmed the structure.

Provenance & Evidence