反应详情

温度

90 °C

10 Grams of 6-carboxy-3,4-dihydrocarbostyril and 6.0 g of N-hydroxysuccinimide were suspended in 200 ml of dioxane. Then a solution of 12.4 g of dichlorohexylcarbodiimide in 50 ml of dioxane was added drop-wise of the suspension under ice-cooling with stirring. The reaction mixture was heated at 90° C. for 4 hours. After the reaction was completed, the reaction mixture was cooled to a room temperature, and the crystals being precipitated were removed by filtration and the mother liquor was concentrated by distillation. The residue was recrystallized from dimethylformamide-ethanol to obtain 10.8 g of succinimide 3,4-dihydrocarbostyril-6-carboxylate.

1. temperaturecooling
2. temperaturethe reaction mixture was cooled to a room temperature
3. customthe crystals being precipitated
4. customwere removed by filtration
5. concentrationthe mother liquor was concentrated by distillation
6. customThe residue was recrystallized from dimethylformamide-ethanol