Potassium Hydroxide → HCID 70510997, compound

HRID 1262875Notes

Reaction equation

HRID 1262875 reaction equation
N#N.C(OC([NH:10][C@@H:11]([C:16]([NH:18][CH2:19][CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:17])[CH2:12][CH2:13][S:14][CH3:15])=O)(C)(C)C.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O.[OH-].[K+].C(OCC)(=O)C.[ClH:50]>C(O)(=O)C>[ClH:50].[C:22]1([CH2:21][CH2:20][CH2:19][NH:18][C:16](=[O:17])[C@@H:11]([CH2:12][CH2:13][S:14][CH3:15])[NH2:10])[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

6

Reactant 4

HCID 14797Potassium HydroxideHCID 14812Phosphorus oxide (P4O10)HCID 21866389Hydrogen chloride-ethyl acetateHCID 86739480HCID 86739480, compound

Product 1

HCID 70510997HCID 70510997, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of N2 -(tert-butyloxycarbonyl)-N-(3-phenylpropyl)-D-methioninamide (1.75 g.) in acetic acid (10 ml.) and hydrogen chloride-ethyl acetate (4 N, 20 ml.) was stirred at room temperature for one hour, then stripped of volatiles under vacuum. A solution of the residue in ethyl acetate-ether was stripped of volatiles under vacuum, finally over phosphorous pentoxide and potassium hydroxide, affording N-(3-phenylpropyl)-D-methioninamide hydrochloride as a vicous oil (1.50 g.).

Sources & evidence

ORD record
ord-24ea06e87b3c4a0c939baf051bf294c0
Source dataset
uspto-grants-1984_06
Patent number
US04454120

Reaction notes

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