Hydrogen Peroxide → HCID 131713559, compound

Participants

Reaction Steps

A solution of L-tyrosyl-N-(3-phenylpropyl)-D-methioninamide monohydrochloride monohydrate (219 mg.) and aqueous hydrogen peroxide (3%, 640 μl) in acetic acid (5 ml.) was stirred at room temperature for two and one quarter hours, then concentrated under vacuum. The residue was reevaporated under vacuum once from ethyl acetate and three times from ether. A solution of the residue in water was filtered and lyophilized, affording as an amorphous white solid L-tyrosyl-N-(3-phenylpropyl)-D-methioninamide S-oxide monohydrochloride sesquihydrate (225 mg.), whose free base is the compound of Formula II wherein Q is Met(O), R1, R2 and R5 are each hydrogen and R4 is (CH2)nY wherein n is 3 and Y is phenyl.

Provenance & Evidence