Diethyl Ether → HCID 70511552, compound

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Reaction Steps

A solution of [N-(tert-butyloxycarbonyl)-O-(tert-butyl)-N-methyl-L-tyrosyl]-N-(3-phenylpropyl)-D-methioninamide (1.9 g.) in hydrogen chloride-dioxane (3.9 N, 25 ml.) was stirred for 75 minutes at room temperature, then stripped of volatiles. Trituration of the residue with ether gave a white powder (1.308 g.), an aqueous solution of which was lyophilized, affording as an amorphous solid N-methyl-L-tyrosyl-N-(3-phenylpropyl)-L-methioninamide monohydrochloride hydrate (4:1) (1.260 g.; [α]D25 +68.0°, c=1, methanol), whose free base is the compound of Formula II wherein Q is Met, R1 is methyl, R2 and R5 are each hydrogen and R4 is (CH2)nY wherein n is 3 and Y is phenyl.

Provenance & Evidence