Hydrogen chloride-ethyl acetate → HCID 86739483, compound

HRID 1262887Notes

Reaction equation

HRID 1262887 reaction equation
[N:1]#[N:2].C(O[C:8]([N:10](C)[C@@H:11]([C:16]([NH:18][CH2:19][CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:17])[CH2:12][CH2:13][S:14][CH3:15])=O)(C)(C)C.C(OCC)(=O)C.[ClH:35]>>[N:1]#[N:2].[ClH:35].[CH3:8][NH:10][C@@H:11]([C:16]([NH:18][CH2:19][CH2:20][CH2:21][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[O:17])[CH2:12][CH2:13][S:14][CH3:15]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86739484HCID 86739484, compound

Product 1

HCID 86739483HCID 86739483, compound

Procedure

A solution of N2 -(tert-butyloxycarbonyl)-N2 -methyl-N-(3-phenylpropyl)-D-methioninamide (3.3 g.) in hydrogen chloride-ethyl acetate (3.4 N, 18 ml.) was stirred for one half hour at room temperature, then stripped of volatiles, affording N2 -methyl-N-(3-phenylpropyl)-D-methioninamide hydrochloride as a crystalline solid (2.5 g., m.r. 107°-110° C.).

Sources & evidence

ORD record
ord-c6572339aabc40dd930dcc9fe27d2772
Source dataset
uspto-grants-1984_06
Patent number
US04454120

Reaction notes

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