Chloroform → HCID 13419961, compound

Participants

Reaction Steps

By the method of part A of Example 5 and using triethylamine instead of diisopropylethylamine and chloroform as a cosolvent with tetrahydrofuran, N-(tert-butyloxycarbonyl)-O-(tert-butyl)-L-tyrosine (2.13 g.) was condensed with N2 -methyl-N-(3-phenylpropyl)-D-methioninamide hydrochloride (2.0 g.). The product, [N-(tert-butyloxycarbonyl)-O-(tert-butyl-L-tyrosyl]-N2 -methyl-N-(3-phenylpropyl)-D-methioninamide, was purified by crystallization, the first crop (1.51 g., m.r. 129°-130° C.) from ethyl acetate, the second crop (0.53 g.) from ethyl acetate-hexane.

Provenance & Evidence