HCID 13419961, compound → HCID 86739486, compound

Participants

Reaction Steps

A solution of [N-(tert-butyloxycarbonyl)-O-(tert-butyl)-L-tyrosyl]-N2 -methyl-N-(3-phenylpropyl)-D-methioninamide (1.81 g.) in hydrogen chloride-ethyl acetate (3.4 N, 20 ml.) was stirred for one hour at room temperature, then stripped of volatiles. The product was crystallized from isopropyl alcohol, affording L-tyrosyl-N2 -methyl-N-(3-phenylpropyl)-D-methioninamide monohydrochloride (966 mg.; m.r. 208°-210° C.; [α]D25 +85.7°, c=1, methanol), whose free base is the compound of Formula II wherein Q is Met, R1 and R5 are each hydrogen, R2 is methyl and R4 is (CH2)nY wherein n is 3 and Y is phenyl.

Provenance & Evidence