Hydrochloric Acid → HCID 86739491, compound

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Reaction Steps

A solution of [N-(tert-butyloxycarbonyl)-O-(tert-butyl)-L-tyrosyl]-N1 -(3-phenylpropyl)-D-glutamamide (700 mg.) in acetic acid saturated with hydrogen chloride (15 ml.) was stirred at room temperature for one hour, then stripped of volatiles under vacuum at 40° C. An aqueous solution of the residue was filtered and lyophilized, affording as an amorphous white solid L-tyrosyl-N1 -(3-phenylpropyl)-D-glutamamide monohydrochloride hydrate (4:3) (545 mg.; [α]D25 +46.4°, c=1, methanol), whose free base is the compound of Formula II wherein Q is Gln, R1, R2 and R5 are each hydrogen and R4 is (CH2)nY wherein n is 3 and Y is phenyl.

Provenance & Evidence