Diisopropylethylamine → HCID 13419969, compound

Participants

Reaction Steps

A solution of N-benzyloxycarbonyl-O-benzyl-L-tyrosine pentafluorophenyl ester (2.34 g.), N-(3-phenylpropyl)-D-serinamide hydrochloride (1.00 g.) and diisopropylethylamine (0.71 ml.) in tetrahydrofuran (25 ml.) was stirred at room temperature for one hour. The mixture was triturated with water, and the product was precipitated with hot ethyl acetate and recrystallized from ethyl acetate, affording (N-benzyloxycarbonyl-O-benzyl-L-tyrosyl)-N-(3-phenylpropyl)-D-serinamide (1.35 g., m.r. 175°-177° C.).

Provenance & Evidence