Sodium Hydroxide → HCID 12962672, compound

HRID 1262936Notes

Reaction equation

HRID 1262936 reaction equation
[OH:1][C:2]1([C:11]2[S:12][C:13]([O:16][CH3:17])=[CH:14][CH:15]=2)C(=O)N[C:5](=[O:9])[NH:4][C:3]1=[O:10].[OH-].[Na+]>>[CH3:17][O:16][C:13]1[S:12][C:11]([CH:2]2[O:1][C:5](=[O:9])[NH:4][C:3]2=[O:10])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 12962671HCID 12962671, compound

Product 1

HCID 12962672HCID 12962672, compound

Procedure

5-Hydroxy-5-(5-methoxy-2-thienyl)-2,4,6(1H,3H,5H)-pyrimidinetrione (1.1 g.) was dissolved in 10 ml. of 1 N sodium hydroxide, allowed to stand for 1.5 hours at room temperature, extracted with ether, acidified with acetic acid, diluted with 15 ml. of water and filtered to yield product [567 mg., m.p. 144°-146° C. (dec.)]. Recrystallization from acetone-hexane gave purified 5-(5-methoxy-2-thienyl)oxazolidine-2,4-dione in two crops [487 mg., m.p. 147°-148° C. (dec.)].

Workup

  1. extractionextracted with ether
  2. additiondiluted with 15 ml
  3. filtrationof water and filtered
  4. customto yield product [567 mg., m.p. 144°-146° C. (dec.)]
  5. customRecrystallization from acetone-hexane
  6. customgave
  7. custompurified 5-(5-methoxy-2-thienyl)oxazolidine-2,4-dione in two crops [487 mg., m.p. 147°-148° C. (dec.)]

Sources & evidence

ORD record
ord-b4a8fba837d047b4a0cdb856dcfe957e
Source dataset
uspto-grants-1984_06
Patent number
US04454320

Reaction notes

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