HuagongsheHuagongshe Chemistry Print Report · For research reference only
Alloxan → 5-(2-chloro-3-thienyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Alloxan | HCID 5781 | — |
| Reactant | 3-Bromo-2-chlorothiophene | HCID 2724559 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-(2-chloro-3-thienyl)-2,4,6(1H,3H,5H)-pyrimidinetrione | HCID 20456472 | — |
Reaction Steps
Following the method of Gronowitz et al. [Chemica Scripta 15, p. 2 (1980)], 2-chloro-3-bromothiophene is reacted with n-butyl lithium in ether at -70° C. After 15 minutes, the organolithium reagent is poured into a solution of alloxan in tetrahydrofuran at -70° C. The reaction mixture is allowed to warm to room temperature for 2 hours, and 5-(2-chloro-3-thienyl)-2,4,6(1H,3H,5H)-pyrimidinetrione isolated according to Example 5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04454320 |
| Source dataset | uspto-grants-1984_06 |
| ORD ID | ord-57e9456397fa4d888db3ca43187e73b4 |
| Source note | uspto-grants-1984_06 |