HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-4-nitrobenzene → 4-Nitrophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-4-nitrobenzene | HCID 7474 | — |
| Reactant | 4,4'-Dichloroazoxybenzene | HCID 11960 | — |
| Reactant | Diazene, 1,2-bis(4-ethoxyphenyl)- | HCID 101783 | — |
| Product | 4-Nitrophenol | HCID 980 | 95% |
Reaction Steps
It has now been found that p-nitrophenetole is obtained with excellent purity and high yields by reaction of p-chloronitrobenzene with ethanol and alkali metal hydroxide in the presence of a phase transfer catalyst, when the reaction is carried out at a temperature in the range of from 60° to 80° C. Thus, a product having a melting point of 58°-59.5° C. and being free from 4,4'-dichloroazoxybenzene, p-chloronitrobenzene, 4,4'-diethoxyazobenzene and p-nitrophenol is obtained with a yield of about 95%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04454355 |
| Source dataset | uspto-grants-1984_06 |
| ORD ID | ord-9845cd312133482ab4966b72b8150927 |
| Source note | uspto-grants-1984_06 |