反应详情

2.0 Grams of 6-[1-oxo-4-(4-phenylpiperazinyl)-butyl]-3,4-dihydrocarbostyril and 0.5 g of palladium black were dispersed in 80 ml of water and stirred at a room temperature under 2 atmospheric pressure of hydrogen gas for 5 hours. The reaction mixture was filtered for removing the palladium black and the mother liquor was concentrated under a reduced pressure and the residue thus obtained was crystallized from acetone and a small amount of ethanol. The crude crystals thus obtained were collected by filtration and recrystallized from isopropanol to obtained 1.5 g of 6-[1-hydroxy-4-(4-phenyl-1-piperazinyl)butyl]-3,4-dihydrocarbostyril in colorless needle like crystals.

1. filtrationThe reaction mixture was filtered
2. customfor removing the palladium black
3. concentrationthe mother liquor was concentrated under a reduced pressure
4. customthe residue thus obtained
5. customwas crystallized from acetone
6. customThe crude crystals thus obtained
7. filtrationwere collected by filtration
8. customrecrystallized from isopropanol