反应详情

To a solution of 13.0 g. (5.46×10-2 moles) of N-(o-nitrobenzyl)ethyl glycine in 200 ml. of absolute ethyl alcohol was added slowly 0.76 g. (5% by weight) of 10% Pd/C catalyst and the mixture placed on a Paar hydrogenator. The mixture was shaken until theoretical hydrogen (16.4×10-2 moles) had been absorbed, removed from the Paar and the mixture filtered under suction. The catalyst was washed with ethyl alcohol and the solvent removed in vacuo affording a yellow oil. Purification of the oil was effected by distillation yielding 8.8 g. (77% yield) of a colorless oil; b.p. 124°-126° C. (0.03 mm).

1. customhad been absorbed
2. customremoved from the Paar
3. filtrationthe mixture filtered under suction
4. washThe catalyst was washed with ethyl alcohol
5. customthe solvent removed in vacuo
6. customaffording a yellow oil
7. customPurification of the oil
8. distillationwas effected by distillation
9. customyielding 8.8 g