Dimethylformamide → 2,2-dimethylpropionyloxymethyl P-ethyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinate

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Reaction Steps

A mixture of P-ethyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinic acid (0.33 g, 0.80 mmol), chloromethyl 2,2-dimethylpropanoate (0.24 g, 1.60 mmol), triethylamine (0.22 ml) and dimethylformamide (DMF) (3 ml) is stirred at RT for 2 days. The reaction is then diluted with methylene chloride, washed, dried and evaporated to dryness, followed by purification by preparative thin layer chromatography (prep. TLC) (silica gel, eluting with 40% ethyl acetate/hexane) to yield 2,2-dimethylpropionyloxymethyl P-ethyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinate.

Provenance & Evidence