Sodium Hydroxide → HCID 13343575, compound

HRID 1263200Notes

Reaction equation

HRID 1263200 reaction equation
[CH3:1][P:2]([CH2:7][O:8][C:9]1[CH:14]=[C:13]([O:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][C:17]=2[Cl:26])[CH:12]=[CH:11][C:10]=1[N+:27]([O-:29])=[O:28])(=[O:6])[O:3]CC.[OH-].[Na+]>C(O)C>[CH3:1][P:2]([CH2:7][O:8][C:9]1[CH:14]=[C:13]([O:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:24])([F:23])[F:25])=[CH:18][C:17]=2[Cl:26])[CH:12]=[CH:11][C:10]=1[N+:27]([O-:29])=[O:28])(=[O:3])[OH:6]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70478700HCID 70478700, compound

Product 1

HCID 13343575HCID 13343575, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To ethyl P-methyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenoxymethylphosphinate (1.30 g) in ethanol (10 ml) is added 5% aq. sodium hydroxide (20 ml) and the solution is stirred at RT for 20 minutes. The ethanol is evaporated off; the aqueous solution is extracted with ether and the ether layer is discarded. The basic aqueous solution is acidified with dilute HCl and extracted with methylene chloride. The combined organic extracts are washed, dried and evaporated to dryness to give P-methyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenoxymethylphosphinic acid (IX; R is NO2, R1 is CH3, R2 =R6 is H, W=X is O, Y is Cl, Z is CF3).

Workup

  1. customThe ethanol is evaporated off
  2. extractionthe aqueous solution is extracted with ether
  3. extractionextracted with methylene chloride
  4. washThe combined organic extracts are washed
  5. customdried
  6. customevaporated to dryness

Sources & evidence

ORD record
ord-c75581aa1899475e8fa994b1b4f8fe4e
Source dataset
uspto-grants-1984_06
Patent number
US04456464

Reaction notes

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