Succinic Acid → 1,4-Bis[2-(2-hydroxyethylamino)ethylamino]-5,8-dihydroxyanthraquinone disuccinate salt

HRID 1263206Notes

Reaction equation

HRID 1263206 reaction equation
[OH:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][NH:7][C:8]1[C:21]2[C:20](=[O:22])[C:19]3[C:14](=[C:15]([OH:24])[CH:16]=[CH:17][C:18]=3[OH:23])[C:13](=[O:25])[C:12]=2[C:11]([NH:26][CH2:27][CH2:28][NH:29][CH2:30][CH2:31][OH:32])=[CH:10][CH:9]=1.[C:33]([OH:40])(=[O:39])[CH2:34][CH2:35][C:36]([OH:38])=[O:37]>C(O)C>[C:33]([OH:40])(=[O:39])[CH2:34][CH2:35][C:36]([OH:38])=[O:37].[C:33]([OH:40])(=[O:39])[CH2:34][CH2:35][C:36]([OH:38])=[O:37].[OH:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][NH:7][C:8]1[C:21]2[C:20](=[O:22])[C:19]3[C:14](=[C:15]([OH:24])[CH:16]=[CH:17][C:18]=3[OH:23])[C:13](=[O:25])[C:12]=2[C:11]([NH:26][CH2:27][CH2:28][NH:29][CH2:30][CH2:31][OH:32])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 1110Succinic AcidHCID 4212Mitoxantrone

Product 1

HCID 867369151,4-Bis[2-(2-hydroxyethylamino)ethylamino]-5,8-dihydroxyanthraquinone disuccinate salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 222 mg. of 1,4-bis[2-(2-hydroxyethylamino)ethylamino]-5,8-dihydroxyanthraquinone, 118 mg. of succinic acid, and 50 ml. of ethanol is heated under reflux for 30 minutes to give the title compound.

Workup

  1. additionA mixture of 222 mg
  2. temperatureunder reflux for 30 minutes

Sources & evidence

ORD record
ord-475d1138020e455ea4c894ef26affdfb
Source dataset
uspto-grants-1984_06
Patent number
US04456552

Reaction notes

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